The corresponding substance of CAS 3380-34-5 is Triclosan, with the chemical name 2,4,4 ‘- trichloro-2′ – hydroxyphenyl ether. It is a broad-spectrum antibacterial agent with the molecular formula C ₁₂ H ₇ Cl ∝ O ₂ and a molecular weight of 289.54.

Basic Information
-Chinese name: Triclosan (alias: Triclosan, Tecoxin)
-English name: Triclosan
-Chemical name: 2,4,4 ‘- Trichloro-2′ – hydroxydiphenyl ether
-Molecular formula: C ₁₂ H ₇ Cl ∝ O ₂
-Molecular weight: 289.54
-CAS number: 3380-34-5
-EINECS number: 222-182-2
-Appearance: White to off white crystalline powder, slightly soluble in water, soluble in organic solvents such as ethanol and acetone, and alkaline solutions

Physical and chemical properties

1. Melting point: 54-60 ° C
2. Boiling point: about 344.6 ° C (atmospheric pressure)
3. Density: Approximately 1.49-1.5 g/cm ³ (25 ° C)
4. LogP: Approximately 5.17 (strongly lipophilic)
5. Water solubility: extremely low, about 10 mg/L (25 ° C)
6. Stability: Stable within the pH range of 1-12, with good thermal stability (does not decompose rapidly at<290 ° C)

Biological activity and application

-Mechanism of action: Specific inhibition of bacterial fatty acid synthase (FabI), blocking fatty acid synthesis, thereby inhibiting/killing bacteria
-Antibacterial spectrum: Effective against Gram positive bacteria, Gram negative bacteria, and some fungi
-Main use: It has been widely used as a preservative or antibacterial additive in personal care products (such as antibacterial soap, toothpaste), medical devices, plastic products, textiles, etc
-Research purpose: As a tool drug for studying bacterial fatty acid synthesis pathways, or for toxicity research related to cell toxicity, endocrine disruption, etc

Security and Regulatory Status
-Toxicity: Acute toxicity is relatively low (oral LD ₅₀ ≈ 4 g/kg in mice), but long-term exposure may involve endocrine disruption, antibiotic resistance, and ecological accumulation risks
-Restrictions: Multiple countries have restricted or banned its use in certain consumer goods, such as hand sanitizer; China has strict limit regulations on its addition in cosmetics
-Storage suggestion: Store in a sealed, dark, and dry place to avoid inhaling dust or direct skin contact

This substance is currently more commonly found in the field of scientific research reagents, and its daily consumer applications have significantly shrunk.

Products :

[CAS 3380-34-5] Triclosan powder (USP standard C12H7Cl3O2)
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