Tert Butyl acetoacetate (tert-Butylacetoacetate), chemical formula C₈H₁₄O3, molecular weight 158.195, CAS number 1694-31-1, is an important organic compound of β – ketoesters

Basic properties
At room temperature, it is a colorless or light yellow transparent liquid with a weak fruity aroma. Its melting point is about -38 ℃, boiling point is between 184-190 ℃, density is about 0.954-1.0 g/cm ³, and flash point is about 60.6 ℃ (closed cup). This substance is slightly soluble in water, but easily soluble in common organic solvents such as ethanol, ether, toluene, etc. Due to the steric hindrance effect of tert butyl, its chemical properties are more stable compared to other acetoacetate esters (such as ethyl acetoacetate), and its hydrolysis reaction is difficult to occur. It also exhibits tautomerism between ketone and enol forms

Main application
This compound has a wide range of applications in multiple fields:
Organic synthesis and pharmaceutical intermediates: As key acetylation reagents and organic synthesis intermediates, they are used to construct complex molecular structures and are important precursors for the synthesis of various quinolone antibiotics, cardiovascular drugs (such as beta blockers), and Bcl-2/Bcl xL inhibitors and other pharmaceutical active ingredients
Industrial solvents and additives: As organic solvents, they are widely used in chemical products such as coatings, paints, adhesives, and cleaning agents. They are also used as enhancers for odors and flavors
Fine chemical raw materials: are key intermediates for the synthesis of dyes, coating additives, pesticides (such as insecticides, fungicides), and ester fragrances

Synthesis and Storage
In industry, tert butanol and diketone are usually used as raw materials and reacted under the action of a catalyst to prepare them. This process has high conversion rate and yield When storing, it should be placed in a cool, dry, well ventilated place, away from heat sources, open flames, and strong oxidants, and the container should be kept sealed.

 
Security Information
This substance is a flammable liquid with slight skin and respiratory irritation
Appropriate protective equipment (such as gloves and goggles) should be worn during operation to ensure good ventilation in the working environment, and relevant chemical safety operation regulations should be strictly followed Its UN dangerous goods number is 3272

Products :

CAS 1694-31-1, tert-Butyl acetoacetate, C8H14O3
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