CAS 28319-77-9 corresponds to L – α – glycerocholine (L – α – GC/Alpha GPC), a natural water-soluble phospholipid metabolite and acetylcholine precursor with the molecular formula C ₈ H ₂ NO ₆ P and a molecular weight of 257.22. It can penetrate the blood-brain barrier for cognitive support and neuroprotection.

Basic Information
-Chinese name: L – α – glycerophosphocholine (alias: glycerophosphocholine, Choline Alfoscerate, Alpha GPC)
-English name: Choline glycerophosphate/L – α – Glycerylphospharylcholine
-Molecular formula: C ₈ H ₂ ₀ NO ₆ P; Molecular weight: 257.22
-Appearance: White to off white solid, highly hygroscopic
-Melting point: 142.5-143 ℃; Specific optical rotation: D ₂₅ -2.7 °~-2.8 ° (aqueous solution)
-Solubility: Easily soluble in water, sparingly soluble in methanol/DMSO; -Sealed storage at 20 ℃
-Source: Naturally present in brain tissue and breast milk, it is often prepared by deacetylation or chemical synthesis of soy lecithin in industry

Core mechanism of action
1. Acetylcholine precursor: It is broken down into choline in the body, efficiently crossing the blood-brain barrier, promoting the synthesis of neurotransmitter acetylcholine, and improving memory and attention.
2. Phospholipid synthesis substrate: Provides a glycerophosphate backbone, participates in the reconstruction of cell membrane phospholipids (such as phosphatidylcholine), and supports neuronal membrane integrity.
3. Neuroregulation: Clinical studies have shown that it has an auxiliary improvement effect on mild cognitive impairment, Alzheimer’s disease, and vascular dementia; It also involves the regulation of growth hormone release.

Main application areas
-Pharmaceutical research and development: therapeutic ingredients for cognitive impairment diseases (Alzheimer’s disease, dementia) (approved in Italy, Japan, etc.)
-Dietary supplements: Brain nutrition ingredients that enhance focus, memory, and exercise performance (accepted for GRAS certification in the United States, approved as a new food ingredient in China in 2024)
-Cosmetics/Food: Skin conditioners, choline enhancing additives (must meet corresponding purity and regulatory requirements)

Safety and Attention
-Generally well tolerated, with occasional mild gastrointestinal reactions and insomnia at high doses (such as>1200mg/day); Moisture proof storage is required.
-Different uses correspond to different purity levels (reagent grade, pharmaceutical grade, food grade), and specifications and qualifications need to be checked when purchasing.

Products :

CAS 28319-77-9 L-A-glycerophosphorylcholine (C8H20NO6P)
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