CAS 1003-78-7 corresponds to 2,4-dimethylsulfolane, a highly polar sulfur-containing heterocyclic solvent with the chemical formula C ₆ H ₁₂ O ₂ S and a molecular weight of 148.22. It is a transparent light brown liquid at room temperature and is mainly used for extraction, separation, and gas chromatography stationary phase.

Core Basic Information
-Chinese name: 2,4-dimethylsulfolane (alias: 2,4-dimethyltetrahydrothiophene-1,1-dioxide, dimethyl sulfone cyclopentane)
-English name: 2,4-Dimethylsulfolane
-Molecular formula/weight: C ₆ H ₁ ₂ O ₂ S/148.22
-IUPAC name: 2,4-dimethylthiolane 1,1-dioxade
-Appearance: Transparent light brown liquid with a slight special odor
-Key physical properties: melting point -3 ℃, boiling point 281 ℃ (partially decomposed), density 1.136 g/mL (25 ℃), refractive index 1.473, flash point approximately 145.6 ℃
-Solubility: Slightly soluble in water; Easy to mix with lower aromatic hydrocarbons, methanol, acetone, and ether

Main purpose and safety
-Application areas: liquid-liquid/gas-liquid extraction solvents (especially for aromatic hydrocarbon/olefin separation); Gas chromatography stationary phase (maximum operating temperature 50 ℃, used for separating lower hydrocarbon isomers and oxygen-containing compounds)
-Toxicity hazard: Belonging to toxic chemicals (GHS category 3), the oral LD of rats is about 100 mg/kg; Irritating to eyes, respiratory tract, and skin
-Storage and transportation requirements: sealed and stored in a cool and dry place, avoiding strong oxidants; Dangerous goods code UN 2810 (Class 6.1), require wearing protective equipment for operation

Regulatory and Hazardous Attributes
Hazard category: This substance is classified as a Class 6.1 toxic substance (UN 2810, packaging category PG III), with significant oral toxicity (LD50 in rats is approximately 100mg/kg), and is irritating to the eyes, respiratory system, and skin.
Safety supervision: As a hazardous chemical, it must strictly comply with the Regulations on the Safety Management of Hazardous Chemicals during production, storage, transportation, and use. Require sealed storage in a cool and dry place, avoiding contact with strong oxidants, and wearing appropriate protective equipment (such as S26/236/37/39).
Usage limitation: Mainly used as a solvent in liquid-liquid and gas-liquid extraction processes. Due to its toxicity, its use in non professional environments is strictly limited to scientific research experiments or industrial production applications, and must be operated by qualified units. ‌‌

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2,4-Dimethylsulfolane CAS 1003-78-7
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