CAS 75-05-8 corresponds to acetonitrile, which is a colorless, flammable, polar non proton solvent with the molecular formula C ₂ H ∝ N and a molecular weight of 41.05. It is widely used in HPLC mobile phase, organic synthesis, and pharmaceutical intermediates.

Core Basic Information
-Chinese name: Acetonitrile (alias: Methyl Cyanide, Cyanomethane)
-English name: Acetyl cyanide, Ethanecitrale
-Molecular formula/structure: C ₂ H ∝ N/CH ∝ CN
-Molecular weight: 41.05 g/mol
-Appearance and odor: Colorless transparent liquid with a pungent odor similar to ether
-Main applications: High performance liquid chromatography (HPLC/LC-MS) mobile phase, organic synthesis solvents/raw materials, pharmaceutical and pesticide intermediates

Key physical and chemical properties
1. Melting point: -48 ℃; Boiling point: 81-82 ℃
2. Density: about 0.786 g/mL (20 ℃); Flash point: 2 ℃ (closed cup)
3. Solubility: miscible with most organic solvents such as water, methanol, acetone, ether, etc
4. Stability: Stable at room temperature, can hydrolyze to produce acetic acid and ammonia under heating or strong acid/alkali conditions, and may release highly toxic hydrogen cyanide (HCN) during high-temperature decomposition

Safety and hazard warning
-Hazard Category: Flammable Liquid (Category 2), Acute Toxicity (Oral/Skin/Inhalation, Category 4), Eye Irritation (Category 2)
-GHS Warning: Highly flammable, harmful by swallowing/skin contact/inhalation, causing eye irritation
-Occupational limit: TWA 20 ppm (34 mg/m ³); There is a risk of combustion and explosion in the presence of open flames, strong oxidants, and alkali metals
-Emergency attention: Poisoning symptoms have a latent period, manifested as nausea, difficulty breathing, convulsions, etc. Immediate medical attention is required and the possibility of cyanide exposure should be informed

Main application areas
-Analytical Chemistry: HPLC and LC-MS preferred mobile phase solvents (high-purity/anhydrous grade required)
-Organic synthesis: Two carbon source raw materials used for the preparation of vitamin B1, pesticides (such as pyrethroids), and pharmaceutical intermediates
-Industrial extraction: nitrile rubber monomer production, C4 fraction extraction solvent
-Nuclear medicine: reaction medium for synthesizing radioactive drugs such as fluorodeoxyglucose (FDG)

Specification

Appearance                                Colorless clear liquid

Purity, %                                    ≥99.00

Molecular Weight                    41.05

Melting point                          −48 °C (lit.)

Boiling point                            81-82 °C (lit.)

Density                                      0.982 g/mL at 20 °C

Storage conditions                  2-8°C

Stability                                    Unstable. Highly flammable. Incompatible with alkali metals,

                                                    acids, bases, reducing agents and oxidizing agents. 

Packing

160kg/drum

Products :

CAS 75-05-8 | Acetonitrile 99.5% (C2H3N)
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