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3-Amino-1-propanol CAS 156-87-6

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CAS 156-87-6 corresponds to 3-amino-1-propanol (also known as n-propanolamine or 3-hydroxypropylamine), with the molecular formula C ∝ H ₉ NO and a molecular weight of 75.11. It is a colorless and hygroscopic liquid mainly used as a key pharmaceutical intermediate for the synthesis of cyclophosphamide, cardiodine, and DL panthenol.

 

 

 

Basic Information
-Chinese name: 3-amino-1-propanol
-English name: 3-Amino-1-propanol
-Common aliases: n-propanol amine, 3-hydroxypropylamine, γ – propanolamine
-Molecular formula: C ∝ H ₉ NO
-Molecular weight: 75.11
-CAS number: 156-87-6
-EINECS number: 205-864-4
- SMILES:NCCCO

 

 

 

Physicochemical properties
-Appearance: Colorless transparent to slightly yellow liquid, hygroscopic, with a slight ammonia odor
-Melting point: 10-12 ° C (literature value about 12.4 ° C)
-Boiling point: 184-188 ° C (atmospheric pressure)
-Density: 0.982 g/mL (20 ° C)
-Refractive index: n ² ⁰/D ≈ 1.460-1.462
-Flash point: 79 ° C
-Solubility: miscible with water, ethanol, ether, and chloroform
-PKa: Approximately 9.96 (25 ° C)
-PH value: 10 g/L aqueous solution, approximately 11.6

 

 

 

main purpose
1. Drug synthesis intermediates: widely used in the synthesis of anti-tumor drugs such as cyclophosphamide and anti angina drugs such as angina pectoris (one of the components of Di’ao Xinxuekang).
2. Vitamin precursor: used for preparing DL panthenol (vitamin B5 derivative).
3. Organic synthesis: As a primary amine and primary alcohol bifunctional reagent, it is used for synthesizing surfactants, resin modifiers, etc.

 

 

 

Safety and Storage
-Hazard category: Corrosive substance (GHS05), Acute toxicity category 4
-Danger signs: Corrosion, Harmful
-UN Number: UN 2735 (Class 8)
-Storage conditions: Sealed and protected from light, stored below 30 ° C, moisture-proof and hygroscopic
-Toxicity reference: Rat oral LD ₅₀ about 1300 mg/kg

 

 

 

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